Bio Microscopy Lab

Peer-Reviewed Publications

Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer. (2026)
S. Ghazanfarpour*, A. Sheikhsofla*, M. Pourrahimi*, S. Sharma, A. Skomra, A. Sharikova, S. A. Schwartz, S. D. Mahajan, A. Khmaladze, R. Aalinkeel
Biochemical and Biophysical Research Communications https://doi.org/10.1016/j.bbrc.2025.151646
Molecular signatures of neuro-HIV and methamphetamine co-morbidity revealed by Raman spectroscopy in postmortem human brain tissue. (2026)
S. Ghazanfarpour*, R. K. Das, K. W. Cheung, E. Zabel, M. Pourrahimi*, R. Aalinkeel, A. Sharikova, A. Khmaladze, S. D. Mahajan
Brain Research https://doi.org/10.1016/j.brainres.2025.150036
Utilizing Machine Learning for Raman Spectral Data Analysis of Brain Tissue. (2026)
S. Ghazanfarpour*, S. Ghazanfarpour*, M. Pourrahimi*, R. K. Das, A. Sharikova, T. Ignatowski, V. P. Muthaiah, S. D. Mahajan, A. Khmaladze
WSEAS TRANSACTIONS on BIOLOGY and BIOMEDICINE https://doi.org/10.37394/23208.2026.23.6
Cryoelectrospun elastin-alginate scaffolds as potential cell delivery vehicles for mesenchymal stromal cell therapy. (2025)
P. Ramesh*, R. Pena*, J. M. Morrissey, N. Moskwa*, K. Tubbesing, X. Zhang, D. Nelson, J. Castracane, A. Khmaladze, S. T. Sharfstein, M. Larsen, Y. Xie
Scientific Reports https://doi.org/10.1038/s41598-025-03822-x
Quantitative phase imaging comparison of digital holographic microscopy and transport of intensity equation phase through simultaneous measurements of live cells. (2023)
Carney, Shane & Khoo, Ting Chean & Sheikhsofla, Alireza & Ghazanfarpour, Samaneh & Sharikova, Anna & Mahajan, Supriya & Khmaladze, Alexander & Petruccelli, Jonathan
Optics and Lasers in Engineering https://doi.org/10.1016/j.optlaseng.2023.107581
Raman Spectroscopy Based Molecular Signatures of Methamphetamine and HIV Induced Mitochondrial Dysfunction (2022)
T. C. Khoo*, R. Aalinkeel, S. Abbasi, S. A. Schwartz, A. Khmaladze, S. D. Mahajan
(Biochem. and Biophys. Res. Comm.) https://doi.org/10.1016/j.bbrc.2022.06.098
Raman Microspectroscopy Fingerprinting of Organoid Differentiation State (2022)
K. Tubbesing, N. Moskwa*, T. C. Khoo*, D. A. Nelson, A. Sharikova, Y. Feng, M. Larsen, A. Khmaladze
(Cell. Mol. Biol. Lett.) https://doi.org/10.1186/s11658-022-00347-3
Automated Quantification of Vomeronasal Glomeruli Number, Size, and Color Composition after Immunofluorescent Staining (2021)
S. J. Bahreini*, J. M. Lin*, F. Etaati, S. Fearnley, J.-F. Cloutier, A. Khmaladze, P. E. Forni
(Chemical Senses) https://doi.org/10.1093/chemse/bjab039
Iron-binding cellular profile of transferrin using label-free Raman hyperspectral imaging and singular value decomposition (SVD) (2021)
K. Tubbesing, T. C. Khoo*, S. J. Bahreini*, A. Sharikova, M. Barroso, A. Khmaladze
(Free Radical Biology and Medicine)
Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV (2021)
C-B. Hsiao, H. Bedi, R. Gomez, A. Khan, T. Meciszewski, R. Aalinkeel, T. C. Khoo, A. Sharikova, A. Khmaladze, S. D. Mahajan
(Vaccines) https://doi.org/10.3390/vaccines9070721
Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID (2021)
E. Clough, J. Inigo, D. Chandra, L. Chaves, J. L. Reynolds, R. Aalinkeel, S. A. Schwartz, A. Khmaladze, S. D. Mahajan
(J Neuroimmune Pharmacol) https://doi.org/10.1007/s11481-021-10015-6
Characterization of Nanofibers for Tissue Engineering: Chemical Mapping by Confocal Raman Microscopy (2020)
A. Sharikova, Z. I. Foraida*, L. Sfakis, L. Peerzada, M. Larsen, J. Castracane, A. Khmaladze
(Spectrochimica Acta Part A) https://doi.org/10.1016/j.saa.2019.117670
Dual wavelength digital holographic imaging of layered structures (2020)
T. C. Khoo*, A. Sharikova, A. Khmaladze
(Optics Comm.)
Comparative phase imaging of live cells by digital holographic microscopy and transport of intensity equation methods (2020)
J. M. Wittkopp*, T. C. Khoo*, S. Carney*, K. Pisila*, S. J. Bahreini*, K. Tubbesing*, S. Mahajan, A. Sharikova, J. Petruccelli, A. Khmaladze
(Optics Express)
Raman Spectroscopy Allows for the Determination of Elephant Ivory Age (2020)
A. Sharikova, L. Peerzada, K. Pisila*, T. C. Khoo*, A. Cherkinsky, A. Khmaladze
(Appl. Spectrosc.)
Quantitative label-free imaging of iron-bound transferrin in breast cancer cells and tumors (2020)
T. C. Khoo*, K. Tubbesing, A. Rudkouskaya, S. Rajoria, A. Sharikova, M. Barroso, A. Khmaladze
(Redox Biology)
Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1 (2020)
J. P. McCauley, M. A. Petroccione, L. Y D’Brant*, G. Todd, N. Affinnih, J. J. Wisnoski, S. Zahid, S. Shree, A. Sousa, R. M. De Guzman, R. Migliore, A. Brazhe, R. D. Leapman, A. Khmaladze, A. Semyanov, D. G. Zuloaga, M. Migliore, A. Scimemi
(Cell Reports)
Methamphetamine-induced apoptosis in glial cells examined under marker-free imaging modalities. (2019)
L. Y. D’Brant*, H. Desta*, T. C. Khoo*, A. Sharikova, S. D. Mahajan, A. Khmaladze
J. Biomed. Opt. 24(4), 046503-1 - 046503-10 https://doi.org/10.1117/1.JBO.24.4.046503
Mesenchymal Cells Affect Salivary Epithelial Cell Morphology on PGS/PLGA Core/Shell Nanofibers (2018)
L. Sfakis*, T. Kamaldinov*, A. Khmaladze, Z. F. Hosseini*, D. A. Nelson, M. Larsen, J. Castracane
(Int. J. Mol. Sci.)
Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway (2018)
A. Sharikova, E. Quaye, J. Y. Park*, M. C. Maloney*, H. Desta*, R. Thiyagarajan, K. L. Seldeen, N. U Parikh, P. Sandhu, A. Khmaladze, B. R. Troen, S. A. Schwartz, S. D. Mahajan
(J. Neuroimmune Pharmacology)

Book Chapters

Nanofiber characterization by Raman scanning microscopy (2020)
A. Khmaladze
(21st Century Nanoscience: A Handbook), Edited by K. Sattler (Taylor and Francis, 2020)

Full Length Conference Proceedings

Assessment of Raman hyperspectral spectra upon depletion of proteins involved in iron transport (2023)
P. Mandal*, A. Sheikhsofla*, S. Ghazanfarpour*, T. C. Khoo*, J. Barra-Carrasco, I. Crousborne, A. Sharikova, A. Khmaladze, M. Barroso
(Proc. SPIE 12391, 123910L)
Quantitative volume comparisons of methamphetamine-induced apoptosis by simultaneous digital holographic microscopy and transport of intensity phase-imaging techniques (2022)
S. Carney*, T. C. Khoo*, K. Tubbesing, A. Sharikova, S. D. Mahajan, J. C. Petruccelli, A. Khmaladze
(Proc. SPIE 11972, 119720B)
The study of cell death mechanisms via simultaneous Raman and transport of intensity phase-imaging techniques (2022)
S. Carney*, T. C. Khoo*, J. Barra-Carrasco, S. Ghazanfarpour*, S. Bahreini*, A. Sharikova, M. Barroso, S. D. Mahajan, J. C. Petruccelli, A. Khmaladze
(Proc. SPIE 12144, 121440A)
Raman mapping of transferrin and ferritin distributions in breast cancer cells (2021)
K. Tubbesing, T. C. Khoo*, A. Sharikova, M. Barroso, A. Khmaladze
(Proc. SPIE 11655, 1165518)
Raman hyperspectral imaging of transferrin-bound iron in T47D and MDA-MB-231 breast cancer cells (2020)
T. C. Khoo*, K. Tubbesing*, A. Rudkouskaya, G. Athanassiadis, A. Sharikova, M. Barroso, A. Khmaladze
(Proc. SPIE 11251, 112511E-1 - 112511E-6)
Detection of the differentiation state of salivary gland organoids for tissue engineering by Raman spectroscopy (2020)
T. C. Khoo*, N. Moskwa*, G. Athanassiadis, A. Sharikova, M. Larsen, A. Khmaladze
(Proc. SPIE 11251, 1125103-1 - 1125103-7)
Measurements of iron-bound transferrin in breast cancer tumor xenografts using Raman spectral imaging (2020)
K. Tubbesing, T. C. Khoo*, A. Rudkouskaya, A. Sharikova, M. Barroso, A. Khmaladze
(Proc. SPIE 11363, 113630Y-1 - 113630Y-6)
Digital holographic microscopy (DHM) and transport of intensity (TIE) phase imaging of live cells (2020)
S. Carney*, T. C. Khoo*, J. Wittkopp*, K. Pisila*, G. Athanassiadis, A. Sharikova, A. Khmaladze, J. Petruccelli
(Proc. SPIE 11251, 1125122-1 - 1125122-6)
Raman hyperspectral imaging of different salivary gland cell types for tissue engineering (2019)
T. C. Khoo*, N. Moskwa*, A. Sharikova, M. Larsen, A. Khmaladze
(Proc. SPIE 10890, 108901S-1 - 108901S-7)
Raman hyperspectral imaging of transferrin-bound iron in cancer cells (2019)
T. C. Khoo*, K. Tubbesing*, C. Pham*, H. Desta*, A. Sharikova, M. Barroso, A. Khmaladze
(Proc. SPIE 10890, 108901S-1 - 108901S-6)
Design of a dual wavelength digital holographic imaging system for the examination of layered structures (2018)
J. C. McFarland*, T. C. Khoo*, A. Sharikova, A. Khmaladze
(Proc. SPIE 10690, 1069013-1 - 1069013-7)
Assessing the age of animal bones and ivories by Raman spectroscopy (2018)
A. Sharikova, L. Peerzada, A. Khmaladze
(Proc. SPIE 10497, 104971B-1 - 104971B-6)
Raman hyperspectral imaging of iron transport across membranes in cells (2016)
A. Das*, F. X. Costa*, A. Khmaladze, M. Barroso, A. Sharikova
(Proc. SPIE 9976, 99760C-1 - 99760C-6)
Digital holographic phase imaging of particles embedded in microscopic structures in three dimensions (2016)
J. Y. Park*, H. Desta*, M. C. Maloney*, A. Sharikova, A. Khmaladze
(Proc. SPIE 9870, 98700B-1 - 98700B-9)
Dual wavelength digital holographic imaging of embedded layered structures (2016)
J. Y. Park*, X. Chen*, A. Sharikova, A. Khmaladze
(Proc. SPIE 9718, 97182J-1 - 97182J-6)
3D measurements of live cells via digital holographic microscopy and terahertz spectroscopy (2016)
J. Y. Park*, D. Oser*, P. Iapozzuto*, S. Norbury*, S. Mahajan, A. Khmaladze, A. Sharikova
(Proc. SPIE 9718, 97182D-1 - 97182D-6)

Shorter Conference Proceedings

In-line Monitoring of Water Quality by Combined Fluorescence and Raman Spectroscopy. (2017)
Maleev, A. Khan*, L Peerzada, A. Khmaladze, A. Sharikova
Imaging and Applied Optics 2016, in OSA CLEO, OSA Technical Digest, Optical Society of America
Examining live cell cultures during apoptosis by digital holographic phase imaging and Raman spectroscopy (2016)
A. Khmaladze
J. Phys.: Conf. Ser. 909, 012001, 1-6 https://doi.org/10.1088/1742-6596/909/1/012001
Phase Imaging of Live Central Nervous System Cells during Apoptosis by Digital Holographic Microscopy (2016)
Y. Park*, M. Maloney*, H. Desta*, S. Mahajan, A. Sharikova, A. Khmaladze
OSA DH, OSA Technical Digest, Optical Society of America